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Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
ISSN: 1995-7262
Vol. 29, No. 1, 2017, pp. 57-60
Bioline Code: mm17012
Full paper language: English
Document type: Case Report
Document available free of charge

Malawi Medical Journal, Vol. 29, No. 1, 2017, pp. 57-60

 en Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy
Nyangulu, Wongani J.S.; Mwinjiwa, Edson; Divala, Titus H.; Mungwira, Randy G.; Nyirenda, Osward; Kanjala, Maxwell; Mbambo, Gillian; Mallewa, Jane; Taylor, Terrie E.; Laurens, Matthew B.; Laufer, Miriam K. & Oosterhout, Joep J. van


We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether–lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

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