Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
Vol. 29, No. 2, 2017, pp. 108-112
Bioline Code: mm17025
Full paper language: English
Document type: Research Article
Document available free of charge
Malawi Medical Journal, Vol. 29, No. 2, 2017, pp. 108-112
© Copyright 2017 - The College of Medicine and the Medical Association of Malawi
Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes|
Nwachukwu, Daniel C.; Eze, Anthonius A.; Nwachukwu, Nkiru Z.; Aneke, Eddy I.; Agu, Polycarp U.; Azubike, Nkiru C.; Obika, Leonard F.O. & Okoye, Onochie I.
Amlodipine and hydrochlorothiazide (HCTZ) are commonly prescribed in Nigeria, either as a monotherapy or in combination with other
drugs. The present study was designed to investigate the antihypertensive efficacy of monotherapy with amlodipine or HCTZ and their
effects on electrolyte profile in patients with mild to moderate hypertension.
A single-blind randomised clinical study design was used; 50 patients newly diagnosed with mild to moderate hypertension (aged 33 to 60
years) were recruited and divided into 2 groups (each with 25 subjects): amlodipine or hydrochlorothiazide. The subjects received either 5
mg of amlodipine or 25 mg of HCTZ, in their respective group, once daily for 4 weeks. Blood pressure and serum and urine electrolytes
were measured at baseline and weekly throughout the experiment.
At the end of follow-up, amlodipine reduced systolic and diastolic blood pressure significantly more (P < 0.001) than HCTZ. At the end
of follow-up, blood pressure was reduced to normal in 80% of the subjects in the amlodipine group, compared to 50% in the HCTZ
group. Amlodipine had no significant effect on electrolyte profiles, unlike HCTZ, which significantly changed both serum and urine
Monotherapy with amlodipine was more effective than HCTZ in patients with mild to moderate hypertension and in addition maintained
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