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Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
ISSN: 1995-7262
Vol. 29, No. 2, 2017, pp. 142-145
Bioline Code: mm17031
Full paper language: English
Document type: Research Article
Document available free of charge

Malawi Medical Journal, Vol. 29, No. 2, 2017, pp. 142-145

 en Human papillomavirus in head and neck squamous cell carcinoma: A descriptive study of histologically confirmed cases at Kamuzu Central Hospital in Lilongwe, Malawi
Faggons, Claire E.; Mabedi, Charles E.; Liomba, N. George; Funkhouser, William K.; Chimzimu, Fred; Kampani, Coxcilly; Krysiak, Robert; Msiska, Nelson; Shores, Carol G. & Gopal, Satish


Head and neck squamous cell carcinoma (HNSCC) is common in sub-Saharan Africa, but the aetiologic contribution of human papillomavirus (HPV) is not well established.
We assessed HNSCC cases for HPV using p16 immunohistochemistry (IHC) in Malawi. Associations between p16 IHC and tumour site, behavioural risk factors, demographic characteristics, and HIV status were examined.
From 2010 to 2014, 77 HNSCC cases were identified. Mean age was 52 years, 50 cases (65%) were male, and 48 (62%) were in the oropharynx (OP) or oral cavity (OC). HIV status was known for 35 patients (45%), with 5 (14%) HIV-infected. Substance use was known for 40 patients (52%), with 38% reporting any tobacco and 31% any alcohol. Forty-two cases (55%) had adequate tissue for p16 IHC, of which 7 (17%) were positive, including 22% of OP/OC tumours.
Despite high cervical cancer burden, HPV-associated HNSCC is not very common in Malawi.

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