About Bioline  All Journals  Testimonials  Membership  News

Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
ISSN: 1995-7262
Vol. 30, No. 4, 2018, pp. 219-224
Bioline Code: mm18045
Full paper language: English
Document type: Research Article
Document available free of charge

Malawi Medical Journal, Vol. 30, No. 4, 2018, pp. 219-224

 en Efficacy of Pterocarpus angolensis check for this species in other resources crude extracts against Candida krusei check for this species in other resources , Staphylococcus aureus check for this species in other resources , Streptococcus agalactiae check for this species in other resources and Escherichia coli check for this species in other resources
Chipinga, Jones Victor; Kamanula, John F. & Moyo, Paul Bisrael Ben


The medicinal plants used to treat different ailments in Malawi contain important phytochemicals which have bactericidal and antifungal properties. Pterocarpus angolensis, locally known as mlombwa tree, which is found in many parts of Malawi, is one such a plant and was studied.
In vitro analysis of the antimicrobial properties of Pterocarpus angolensis crude extracts on Staphylococcus aureus, Escherichia coli, Streptococcus agalactiae, Candida krusei and determination of the phytochemicals there in.
In this study, different organs of P. angolensis, a medicinal plant which is locally used to treat skin diseases, were qualitatively screened for the presence of phytochemical constituents and quantitatively assayed for the antimicrobial activity to ascertain their pharmaceutical potential. The aqueous, dichloromethane and methanolic extracts of the leaves, stem-bark, fruits and roots of the plant were tested against Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae and Candida krusei by the macro tube dilution method. These pathogens were selected due to their significant contribution to infectious disease burden of most hospitals and also the fact that of late, they have shown signs of resistance to conventional antibiotics.
The study revealed that P. angolensis contained tannins, flavonoids, saponins and terpenoids. All the extracts exhibited some antimicrobial activity against the test organisms. However, the activity of the extracts depended on concentration and microbial species. The minimum inhibition concentration (MIC) values of the extracts ranged from 0.166 g/ml to 0.01046 g/ml with the dichloromethane and methanolic extracts exhibiting more activity than the aqueous extracts. The minimum bactericidal concentration and minimum fungicidal concentration (MBC and MFC respectively) values of the extracts ranged from 0.166 g/ml to 0.0417 g/ml.
The results obtained indicate that Pterocarpus angolensis has both antibacterial and antifungal properties and could be used for the treatment of Taenia capitis (ring worm) and other ailments. Use of the isolated and purified compounds from P. angolensis could increase the susceptibility of the tested pathogenic microorganisms in this study.

Efficacy; Crude Extracts; Minimum Bactericidal Concentration (MBC); Minimum Inhibitory Concentration (MIC); Minimum Fungicidal Concentration (MFC); phytochemical.

© Copyright 2018 - The College of Medicine and the Medical Association of Malawi
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil