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Long-term pruritus as the initial and sole clinical manifestation of occult Hodgkin's disease Omidvari Shapour H, Khojasteh Habib Noorani , Mohammadianpanah Mohammad , Monabati Ahmad , Mosalaei Ahmad , Ahmadloo Niloofar Abstract Pruritus or itch is a frequent symptom of patients with Hodgkin's disease. It often occurs during the clinical course of the disease and rarely may precede the diagnosis of underlying disease. In this report, we present a 16-year-old patient who had history of generalized pruritus without any skin rash for 4 years before the diagnosis of Hodgkin's disease. Within that period, she had received symptom-oriented medications, with no significant effect. After the first cycle of chemotherapy, her pruritus resolved completely. This case suggests that long-term generalized pruritus may be indicative of a significant underlying problem like Hodgkin's disease. Keywords Hodgkin's disease, long-term generalized pruritus, manifestation, chemotherapy, lymphoproliferative disorders

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