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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359
EISSN: 1998-3654
Vol. 60, No. 2, 2006, pp. 64-67
Bioline Code: ms06011
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Medical Sciences, Vol. 60, No. 2, 2006, pp. 64-67

 en Case Report- Paroxysmal nocturnal hemoglobinuria in childhood: An uncommon presentation
Gupta Vineeta, Tilak V, Ramakrishna SV.K., Bhatia BD

Abstract

An eight year old boy presented with severe anemia and bleeding spots. Complete blood count showed pancytopenia. There was mild reticulocytosis. Bone marrow was hypocellular with normoblastic erythroid hyperplasia. Ham's test (acidified serum test) was positive which confirmed the diagnosis of Paroxysmal nocturnal hemoglobinuria (PNH). Although PNH is rare in childhood, it should be considered as a diagnostic possibility in cases of aplastic anemia as the two conditions can coexist. The presence of PNH in association with aplastic anemia can influence the outcome of the latter.

Keywords
Paroxysmal nocturnal hemoglobinuria, aplastic anemia, pancytopenia

 
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