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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359
EISSN: 0019-5359
Vol. 64, No. 12, 2010, pp. 556-559
Bioline Code: ms10005
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Medical Sciences, Vol. 64, No. 12, 2010, pp. 556-559

 en Ceftriaxone resistant Shigella flexneri check for this species in other resources , an emerging problem
Gupta, Soham; Mishra, Baijayanti; Muralidharan, Sethumadhavan & Srinivasa, Hiresave

Abstract

Shigellosis is a disease of public health importance in developing countries. It may cause self-limited diarrhea to severe dysentery. Emergence of multi drug resistant (MDR) strains is a growing concern globally. Ceftriaxone and ciprofloxacin are the drugs of choice for MDR cases. Here, we report a case of MDR Shigella flexnerifrom an immunocompromised patient. The strain was resistant to ceftriaxone [minimum inhibitory concentration (MIC) ≥ 64 μg/ml], limiting the treatment option. Simultaneously, the strain was also found to be resistant to ciprofloxacin (MIC ≥ 4 μg/ml). However, it was susceptible to ceftazidime (MIC 4 μg/ml). This is the first case of ceftriaxone resistant Shigella spp. reported from our hospital.

Keywords
Ceftriaxone, extended spectrum beta lactamase, minimum inhibitory concentration, multi drug resistant, Shigella flexneri

 
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