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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 50, No. 1, 2002, pp. 60-62
Bioline Code: ni02014
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 50, No. 1, 2002, pp. 60-62

 en Correlation of Serum and Salivary Carbamazepine Concentration in Epileptic Patients : Implications for Therapeutic Drug Monitoring
A. Vasudev, K.D. Tripathi, V. Puri


Therapeutic drug monitoring (TDM) of carbamazepine (CBZ) in saliva is an attractive alternative, because its collection is painless, non-invasive and simpler than drawing blood. Salivary drug levels, also closely reflect the free drug concentration. The aim of the study was to evaluate the suitability of saliva in routine TDM of CBZ in adult epileptic patients. Blood and saliva samples were taken simultaneously at 0 hours and 24 hours of CBZ dosing from 31 epileptic patients, receiving CBZ monotherapy for three or more months. Levels of CBZ in both these fluids were measured by high performance liquid chromatography. Strong and highly significant correlation was found between serum and salivary CBZ concentration (r = 0.659, p<0.001). Estimation of CBZ level in saliva is thus a practicable, valid and convenient method of TDM in epileptic patients.

Carbamazepine, Saliva, TDM

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