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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 50, No. 4, 2002, pp. 417-423
Bioline Code: ni02115
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 50, No. 4, 2002, pp. 417-423

 en Review Article - Landau Kleffner Syndrome : Electroclinical and Etiopathogenic Heterogeneity
M.B. Singh, J. Kalita, U.K. Misra


Landau - Kleffner syndrome is a rare, functional, age-related epilepsy with aphasia and epileptiform discharges on EEG. The heterogenity of clinical presentations, course, longterm outcome and response to treatment suggests multiple underlying etiologies. Normal children abruptly develop deterioration of language functions along with spike and wave discharges on EEG. Clinical seizures may or may not be present. The aphasia responds poorly to most drugs. Valproic acid and benzodiazepines are most effective. Steroids and intravenous immunoglobulins have shown a variable response. Long-term outcome of aphasia is variable, many patients persist with residual impairment. Important questions regarding etiopathogenesis are unanswered.

Landau-Kleffner syndrome, Aphasia, Spike and wave

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