Medknow Publications on behalf of the Neurological Society of India
Vol. 51, No. 4, 2003, pp. 466-469
Bioline Code: ni03152
Full paper language: English
Document type: Research Article
Document available free of charge
Neurology India, Vol. 51, No. 4, 2003, pp. 466-469
© Copyright 2003 Neurology India. Online full text also at http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=4;spage=466;epage=469;aulast=Sinha
Nervous system involvement in asymptomatic HIV seropositive individuals: A cognitive and electrophysiological study|
Sinha S, Satishchandra P
Background: A significant proportion of human immunodeficiency virus (HIV) seropositive subjects may have subclinical asymptomatic involvement of the central and peripheral nervous system. Aims: To detect subclinical neurological involvement in asymptomatic HIV seropositive individuals by clinical, mini mental state examination (MMSE) and various electrophysiological tests. Material and Methods: MMSE, EEG, nerve conduction (NC), and multimodality-evoked potential studies were evaluated in 20 asymptomatic HIV seropositive subjects. Results: The majority of the subjects were young (mean age: 29.5 ± 8.9 yrs) and female (85%). The mean MMSE score was 25.8 ± 2.3, which was marginally less than that of matched controls (26.3 ± 2.4). Four subjects had a score of less than 23 suggesting subclinical cognitive impairment. EEG (n=19) was mildly abnormal in 8 cases: low alpha index (n=4), excess of fast background activity (n=3) and intermittent bursts of slow waves along with sometimes sharp waves (n=4). Motor NC studies (n=20) revealed a decreased mean nerve conduction velocity (NCV) compared to controls in the right median (P<0.05) and CP (P<0.001) nerves. Sensory NC studies revealed a decreased mean NCV in both the median (P<0.001) and sural (P<0.001) nerves compared with controls. Brainstem auditory evoked potential (BAEP) studies showed the involvement of the peripheral auditory pathway (23.5%). The somatosensory evoked potential (SSEP) study detected a delay of N20 latency in two. Only 3 subjects came for follow-up after 6 months. Conclusion: Asymptomatic HIV seropositive subjects may have subclinical central and peripheral nervous system involvement. Long-term follow-up studies are essential for better understanding of the significance of these changes.
Asymptomatic HIV seropositive, Cognition, EEG, Evoked potential, ENMG.
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