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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 53, No. 2, 2005, pp. 162-166
Bioline Code: ni05047
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 53, No. 2, 2005, pp. 162-166

 en Primary progressive aphasia: A comparative study of progressive nonfluent aphasia and semantic dementia
George Annamma, Mathuranath P.S.

Abstract

Primary progressive aphasia (PPA), a degenerative disorder, is often misdiagnosed as Alzheimer′s disease. Its subtypes, semantic dementia (SD), and progressive nonfluent aphasia (PNFA), are often difficult to differentiate from each other. Our objective was to highlight the differences in the language profiles of patients with SD and PNFA. To bring out these differences, we report two patients with PPA, one with SD and the other with PNFA. They were administered the Western aphasia battery (WAB) and a semantic battery, which assesses semantic memory. The profiles of language impairment on the WAB indicated that the patient with PNFA had syntactic errors in expressive speech but relatively preserved semantics and comprehension, whereas the patient with SD had preserved syntax but made semantic errors in expressive speech, and had impaired comprehension. There were differences in their performance on the semantic battery too. The patient with SD made relatively less errors on confrontation naming, although on the pointing task he failed to point to those line drawings, which he was unable to name on confrontation. In contrast, the finding of the PNFA patient was the reverse of this. Supplementing conventional neuropsychological tests with formal tests for assessment of language functions is useful in the early diagnosis of PPA. The performance of PPA patients on a detailed assessment of language that includes use of formal tests such as the semantic battery helps to differentiate PNFA from SD.

Keywords
Dementia, language, neuropsychology, primary progressive aphasia, semantic

 
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