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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 53, No. 3, 2005, pp. 297-301
Bioline Code: ni05103
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 53, No. 3, 2005, pp. 297-301

 en Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario
Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP

Abstract

Background : Hyperhomocysteinemia has been proposed as an important risk factor for ischemic stroke worldwide, but data available from the Indian subcontinent is scarce.
Aim : To study homocysteine levels in patients with ischemic stroke and compare it with age- and sex-matched controls.
Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30 controls were recruited for the study. They were subdivided into two subgroups (<40 years and >40 years of age) and plasma fasting total homocysteine (tHcy) levels were measured.
Statistical analysis used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke, compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P < 0.001). Significantly high levels were seen in both male patients compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72 μmol/l; P = 0.01) and female patients compared to controls (9.08 ± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy levels were significantly high in patients with hypertension compared to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important independent risk factor for ischemic stroke. A strong positive correlation was also observed between hypertension, smoking, and high-tHcy levels in the present study.

Keywords
Case-control study; homocysteine; ischemic stroke.

 
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