Medknow Publications on behalf of the Neurological Society of India
Vol. 54, No. 1, 2006, pp. 24-27
Bioline Code: ni06004
Full paper language: English
Document type: Research Article
Document available free of charge
Neurology India, Vol. 54, No. 1, 2006, pp. 24-27
© Copyright 2006 Neurology India.
Review Article - Early recombinant factor VIIa therapy in acute intracerebral hemorrhage: Promising approach|
Kumar Sudhir, Badrinath HR
Intracerebral hemorrhage (ICH) is the most devastating form of stroke with a high morbidity and mortality. ICH constitutes about 20-30% of all strokes, with the prevalence being higher in Asian population. Treatment of ICH is predominantly conservative, which includes control of blood pressure, use of anti-cerebral edema measures such as mannitol and mechanical ventilation. The benefit of early surgery in ICH is debatable. Initial hematoma volume and subsequent growth in its size are important predictors of a poor outcome in ICH. This means that therapies aimed at preventing hematoma enlargement in the earliest possible window period could lead to a better outcome in ICH. Recombinant factor VIIa (rFVIIa) is one such agent, which has been shown to prevent hematoma expansion and improve outcome in acute ICH. The purpose of the current review is to focus on the evidence regarding the usefulness of rFVIIa in acute ICH.
Recombinant factor VIIa, Acute intracerebral hemorrhage.
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