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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 54, No. 4, 2006, pp. 366-369
Bioline Code: ni06131
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 54, No. 4, 2006, pp. 366-369

 en Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population
Lai Jiangtao, Zhou Dongchen, Xia Shudong, Shang Yunpeng, Zhu Jianhua, Pan Jiaqi, Hua Baolai, Zhu Yicheng, Cui Liying


Background and Aims: Chronic inflammatory process plays an important role in atherothrombosis. Interleukin-1 (IL-1) is one of the key modulators of the inflammatory response and its activity is critically regulated by its receptor antagonist (IL-1Ra). A variable number tandem repeat polymorphism in intron 2 of IL-1Ra gene and a C to T single base polymorphism in the promoter of IL-1β gene (C-511 →T) have been reported to affect the levels of IL-1 as well as its antagonist, IL-1Ra. It is also reported in several studies that these polymorphisms are associated with the susceptibility to cardio-cerebral vascular disease. However, data are limited in China. In this article, we studied the relationships between these polymorphisms and the risk of ischemic stroke in China.
Materials and Methods: One hundred and twelve patients committed ischemic stroke were compared with 95 demographically matched healthy volunteers.
Results: The frequencies of the IL-1Ra 1/1 genotype and IL-1Ra allele 1 (RaFNx011 allele) in stroke patients were significantly higher than those in healthy volunteers [93.7% vs. 82.1%, P =0.014; 0.964 vs. 0.905, P =0.007]. No significant differences were found in the IL-1β -511 genotype and the allele distribution between the two groups.
Conclusions: Our results implicated that IL-1 gene polymorphism might be associated with the susceptibility to ischemic stroke.

Cerebrovascular accident, genetics, interleukins, polymorphism

© Copyright 2006 Neurology India.
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