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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 54, No. 4, 2006, pp. 418-420
Bioline Code: ni06143
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 54, No. 4, 2006, pp. 418-420

 en Case Report - Sporadic onset Creutzfeldt-Jacob disease: Interesting MRI observations
Praveen KS, Sinha S, Chandrasekhar HS, Vijayan J, Taly AB


We describe a 60-year-old woman with "probable" sporadic Creutzfeldt-Jacob disease (CJD) who manifested with two months history of rapidly progressive dementia and abnormal behavior, speech and gait abnormality, excessive sleepiness and myoclonic jerks. Scalp EEG showed diffuse slowing of background activity to delta range and triphasic sharp wave complexes occurring periodically twice in one-second interval. Magnetic resonance Imaging (MRI) of brain revealed high signal intensity on T2 weighted image (T2WI) and fluid attenuated inversion recovery sequences in the caudate and putamen bilaterally. Diffusion weighted images showed bilateral symmetric hyperintense signals in the caudate and putamen. The role of MRI in the diagnosis of CJD is discussed.

Creutzfeldt-Jacob disease, creutzfeldt-jacob disease, magnetic resonance Imaging, rapidly progressive dementia

© Copyright 2006 Neurology India.
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