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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 55, No. 1, 2007, pp. 64-66
Bioline Code: ni07018
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 55, No. 1, 2007, pp. 64-66

 en Case Report - Intraosseous malignant peripheral nerve sheath tumor with focal epithelioid differentiation of the thoracic spine
Miyakoshi Naohisa, Nishikawa Yuji, Shimada Yoichi, Okada Kyoji, Yoshida Masayuki, Enomoto Katsuhiko, Itoi Eiji


The authors describe an extremely rare case with malignant peripheral nerve sheath tumor (MPNST) with focal epithelioid differentiation presenting as an intraosseous lesion of the spine. A 75-year-old woman presented with progressive paraplegia caused by epidural mass arising from the posterior element of the T7 vertebra. At surgery, the lesion was noted to originate from the T7 vertebra and separate from the dura and spinal nerve roots. The patient died of tumor metastases to the lungs six months after the initial presentation. Histological diagnosis was MPNST. However, the tumor also contained cystic structures lined by epithelioid cells, requiring differentiation from synovial sarcoma. From the histological and immunohistochemical features, as well as the absence of SYT-SSX fusion gene expression, the diagnosis of MPNST with focal epithelioid differentiation was made. This is the first case report of intraosseous MPNST of the spine with a peculiar biphasic appearance.

Epithelioid differentiation, intraosseous tumor, malignant peripheral nerve sheath tumor, spine

© Copyright 2007 Neurology India.
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