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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 1998-4022
Vol. 55, No. 4, 2007, pp. 385-387
Bioline Code: ni07112
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 55, No. 4, 2007, pp. 385-387

 en Case Report - Magnetic resonance spectroscopy study in basal ganglia of patients with myoclonic epilepsy with ragged-red fibers
Chuang, Chieh-Sen; Lo, Man-Chi; Lee, Kwo-Whei & Liu, Chin-San

Abstract

Abnormal magnetic resonance spectroscopic (MRS) signals in the basal ganglia may be one of the characteristics in mitochondrial disease. We report MRS study in a family with myoclonic epilepsy with ragged-red fibers (MERRF). Their MRS studies over the basal ganglia revealed decreased N-acetylaspartate/creatine ratio and increased choline/creatine ratio in the four symptomatic members, but normal in the two asymptomatic members. However, negative MRI study was found in all members of this family. Our report suggests that the increased choline/creatine ratio in basal ganglia MRS may be one of the early information to suspect MERRF disease.

Keywords
Magnetic resonance spectroscopy, myoclonic epilepsy with ragged-red fibers

 
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