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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 56, No. 2, 2008, pp. 198-200
Bioline Code: ni08053
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 56, No. 2, 2008, pp. 198-200

 en Miller-Fisher syndrome associated with chronic lymphocytic leukemia
Aki, Zeynep; Aksoy, Ozlem; Sucak, Gulsan; Kuruoglu, Reha & Yagci, Munci

Abstract

Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.

Keywords
Chronic lymphocytic leukemia, Miller-Fisher syndrome, plasmapheresis

 
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