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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 57, No. 1, 2009, pp. 69-72
Bioline Code: ni09018
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 57, No. 1, 2009, pp. 69-72

 en The influence of hypoglycemia on cerebral blood flow in cases of hypoglycemic coma
Terakawa, Yuzo; Tsuyuguchi, Naohiro; Yamamura, Akinori & Nakagawa, Toshio


The authors report two cases of hypoglycemic coma in which both diffusion-weighted imaging (DWI) and single photon emission computed tomography (SPECT) were used. A 74-year-old woman (case 1) presented with deep coma associated with hypoglycemia (blood glucose level: 20 mg/dl), and DWI on admission revealed extensive hyperintensity lesions. SPECT obtained on the second hospital day revealed diffuse hyperperfusion and a follow-up SPECT on the eighth hospital day showed relative hypoperfusion. An 89- year- old woman (case 2) presented with coma associated with hypoglycemia (blood glucose level: 45 mg/dl), and DWI showed diffuse hyperintensity lesions in both hemispheres. SPECT obtained on the ninth hospital day showed relative hypoperfusion compared to the first scan obtained on the third hospital day. Although the blood glucose level was rapidly corrected, the level of consciousness remained unchanged in both cases. Our results suggest that cerebral blood flow may increase even after glucose correction and that relative hypoperfusion could occur in the subacute stage of hypoglycemic coma.

Cerebral blood flow, diffusion-weighted imaging, hypoglycemia, hypoglycemic coma, single photon emission computed tomography

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