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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 58, No. 2, 2010, pp. 316-318
Bioline Code: ni10080
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 58, No. 2, 2010, pp. 316-318

 en Primary pituitary fibrosarcoma presenting with multiple metastases: A case report and literature review
Li, Zhao-Jian; Sun, Peng; Guo, Yi & Wang, Ren-Zhi


Even though many cases of pituitary fibrosarcoma (PF) have been reported, the etiologic classification of these tumors, however, remains undefined. Moreover, owing to the paucity of available case studies, the clinical characteristics of primary pituitary fibrosarcoma (PPF) have not been fully described. We report a 26-year-old female with pathologically confirmed PPF, who presented with features of elevated intracranial pressure, oculomotor nerve palsy, field defects and panhypopituitarism. Despite the combination therapy, which included tumor removal, radiotherapy, and chemotherapy, magnetic resonance imaging demonstrated multiple intracranial and extracranial metastases at a seven-month follow-up, and the survival duration from diagnosis was only 11 months. Based on a review of the literature, we propose preliminary etiologic classification criteria for PF as well as a new therapeutic approach to reduce PPF recurrence and metastasis, including extended surgical resection and postoperative whole-brain radiotherapy.

Metastases, pituitary fibrosarcoma, pituitary adenoma, radiotherapy

© Copyright 2010 Neurology India.
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