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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 1998-4022
Vol. 58, No. 3, 2010, pp. 449-451
Bioline Code: ni10114
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 58, No. 3, 2010, pp. 449-451

 en Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast
Agarwal, Pankaj A. & Ichaporia, Nasli R.

Abstract

Stiff limb syndrome (SLS) is a rare "focal" variant of stiff person syndrome which presents with rigidity and painful spasms of a distal limb, and abnormal fixed foot or hand postures. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) are variably present in most cases. Most reported cases of SLS are unassociated with cancer. We describe a patient with SLS as a paraneoplastic manifestation of breast carcinoma, in whom GAD-Ab was present. The patient responded very well to oral diazepam, baclofen and steroids.This is the third reported case of SLS as a paraneoplastic accompaniment to cancer.

Keywords
Glutamic acid decarboxylase antibody, paraneoplastic, stiff limb syndrome

 
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