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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 59, No. 3, 2011, pp. 339-343
Bioline Code: ni11106
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 59, No. 3, 2011, pp. 339-343

 en Non-normalized individual analysis of statistical parametric mapping for clinical fMRI
Nagata, Takashi; Tsuyuguchi, Naohiro; Uda, Takehiro & Ohata, Kenji


Background : Pre-operative evaluation to localize function within the cerebral cortices is essential before brain surgery. Blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) has been used for this purpose.
Aims : To obtain clearer and more understandable functional images.
Patients and Methods : Ten patients with brain tumors underwent fMRI including hand-gripping and word generation tasks. The statistical parametric mapping (SPM) approach was used for subsequent analysis to localize the motor or language functions. SPM includes image pre-processing, statistical computation, and significance testing. In order to demonstrate a spatial relationship between the lesions and a functioning area in the individual structural MR images, normalization to the Montreal Neurological Institute coordinates was intentionally not performed.
Results : In seven cases out of 10, the patient's motor area was clearly visualized. Language areas were also demonstrated in seven cases.
Conclusions : We conclude that application of SPM (version 8) analysis to non-normalized individual data for the purpose of performing pre-operative fMRI is a useful method for investigation of functional localization.

Analysis, clinical, functional magnetic resonance imaging, non-normalized, statistical parametric mapping

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