About Bioline  All Journals  Testimonials  Membership  News

Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 59, No. 4, 2011, pp. 521-526
Bioline Code: ni11163
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 59, No. 4, 2011, pp. 521-526

 en Association of atherosclerotic cerebral infarction and human leukocyte antigen-DRB in a North Chinese Han population
Liu, Song-Yan; Chang, Ying; Zhang, Shuang-Yan; Wu, Wei; Sun, Bo-Jian & Han, Xue-Mei


Background and Objectives: Evidence from experimental and genetic studies suggest the existence of a potential link between the polymorphisms of human leukocyte antigen class II gene (HLA-DR) and ischemic stroke. This study addressed the association of HLA-DR gene with atherosclerotic cerebral infarction (ACI) in a North Chinese Han population.
Material and Methods: The genotyping of HLA-DRB1 was determined by standard techniques based on polymerase chain reaction and sequence-specific oligonucleotides hybridization in a gene chip.
Results: The relative risk (RR) of HLA-DRB1*04 and HLA-DRB1*03 (17) in patients with ACI and their first-degree relatives were significantly higher than those in the control group (RR=2.56 and 18.77, respectively; P <0.05). In contrast, the RR of HLA-DRB1*12 was dramatically reduced in patients with ACI in relation to healthy controls (RR=0.17; P <0.01).
Conclusions: These data indicate that the polymorphisms in HLA-DRB1 may influence the risk of ACI in the North Han population of China. Further studies are necessary to validate the observation in larger samples.

Atherosclerotic cerebral infarction, gene chip, Han nationality, human leukocyte antigen, north china

© Copyright 2011 Neurology India.
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil