search
for
 About Bioline  All Journals  Testimonials  Membership  News


Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 18, No. 1-2, 2003, pp. 27-30
Bioline Code: np03007
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 18, No. 1-2, 2003, pp. 27-30

 en GASTRIC ULCEROGENIC ACTIVITIES OF Piper guineense check for this species in other resources EXTRACT IN RATS
Y. RAJI, U.S. UDOH AND O.O. OJO

Abstract

Administration of Piper guineense check for this species in other resources fruit extract caused a dose - dependent mortality rate in rats. Doses of 200 mgkg-1 intravenously, (i.v); 300 mgkg-1 intraperitoneally, (i.p) and 3200 mgkg-1 orally( p.o) produced 100% mortality rate - giving LD50 of 85.1 mgkg-1 i.v ; 224 mgkg i.p and 1122 mgkg-1 p.o respectively. Piper extract significantly stimulated gastric ulceration, total gastric acidity and in situ gastric acid secretion in rats. Piper-induced gastric ulceration appears to be similar to that induced by indomethacin (40 mgkg-1 b.w). Atropine produced no effect on the stimulatory action of piper on gastric acid secretion. However, gastric acid secretion in the presence of histamine, and cimetidine appears to be augmented by piper extract (25 mgkg-1 b.w). The results suggest that piper could stimulate gastric acid secretion (and probably gastric ulceration) via the H2 - receptor potentiation.

Keywords
Piper guineense, ulceration, rats

 
© Copyright 2003 - Physiological Society of Nigeria

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil