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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 20, No. 1-2, 2005, pp. 74-78
Bioline Code: np05014
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 20, No. 1-2, 2005, pp. 74-78

 en INFLUENCE OF NITRIC OXIDE ON HISTAMINE AND CARBACHOL – INDUCED GASTRIC ACID SECRETION IN THE COMMON AFRICAN TOAD – BUFO REGULARIS check for this species in other resources
A. R. A., ALADA, H. M. SALAHDEEN, O.O. AKANDE AND G.O. IDOLOR

Abstract

The study aimed to determine the influence of nitric oxide (NO) on the action of histamine and carbachol on acid secretion in the common African toad – Bufo regularis check for this species in other resources . Gastric acidity was determined by titration method. The acid secretion was determined when nitric oxide was absent following administration of NO synthase inhibitor; N-nitro-L-arginine methyl ester (L-NAME) and when nitric oxide was in excess by administration of exogenous NO donor, sodium nitroprusside (SNP). Histamine or carbachol increased acid secretion in the toad. Acid output increased from 0.32 ± 0.04 mEq/15min to 0.56 ± 0.08 and 0.61 ± 0.05 mEq/15min for histamine and carbachol respectively (P < 0.05). Pretreatment of the toad with L-NAME produced further increases in histamine (0.62 ± 0.06 mEq/15min) or carbachol (0.74 ± 0.06 mEq/15min) induced acid secretion respectively. SNP however, completely abolished the acid secretion stimulated by either histamine or carbachol. It was therefore concluded that nitric oxide has a negative influence on the histamine or carbachol – stimulated acid secretion in the toad – Bufo regularis.

Keywords
Nitric oxide, Histamine, Carbachol, Acid secretion.

 
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