search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 20, No. 1-2, 2005, pp. 90-94
Bioline Code: np05017
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 20, No. 1-2, 2005, pp. 90-94

 en EFFECT OF OVARIECTOMY ON THE LEVELS OF PLASMA SEX HORMONES IN ALBINO RATS
E. A. ALAGWU., R. O. NNELI

Abstract

The study was carried out to evaluate the levels of sex hormones (testosterone, progesterone & estradiol), six weeks post normal ovariectomy as against estimating the levels immediately or less 48 hours after operation. 28 adult female albino rats of Wistar strain were used. They were fed twice a day with Guinea pellets and tap water was offered ad libitum. The animals were grouped into three. Group one was sham operated and served as the control, group two was unilaterally ovariectomised (right removed), group three was bilaterally ovariectomised. The animals were sacrificed at the end of the study by decapitation and the blood collected and assayed for sex hormones. The levels of the sex hormones were measured using radioimmunoassay technique. The results showed significant increase in testosterone level in group 3 with decrease in group 2 which was not significant when compared to group 1. On the progesterone levels, there were significant decrease in group 3 and not 2 when compared to group 1. Estradiol level showed significant decrease in only group 3. The decrease in group 2 was not significant when compared with the control. This work therefore does not propose a longer period of hormonal estimation beyond 48 hours following ovariectomy as the results obtained 6 weeks post ovariectomy did not differ or alter significantly beyond 48 hours when compared with the work of Bast and Greenwald 1977, Bulcher 1977, De Jong et al 1978. It is therefore concluded that sex hormone values obtained 6 weeks after normal ovariectomy did not differ significantly as was observed by various workers and confirmed by the present study.

Keywords
ovariectomy, sex hormone, Estradiol

 
© Copyright 2005 - Physiological Society of Nigeria

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2019, Site last up-dated on 17-Apr-2019.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil