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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 21, No. 1-2, 2006, pp. 1-4
Bioline Code: np06001
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 21, No. 1-2, 2006, pp. 1-4

 en COMPARATIVE EFFECT OF CAROTENOID COMPLEX FROM GOLDEN NEO-LIFE DYNAMITE (GNLD) AND CARROT EXTRACTED CAROTENOIDS ON IMMUNE PARAMETERS IN ALBINO WISTAR RATS
V. S. EKAM, E. O. UDOSEN and A. E. CHIGBU

Abstract

The immunomodulatory effect of Carotenoid complex from Golden Neo-Life Dynamite (GNLD) and carrot extracted Carotenoid was assessed using 24 albino Wistar rats. The rats were assigned to 4 groups of 6 rats each consisting of group 1(control group treated with distilled water), group 2 (treated with olive oil), group 3 (treated with carrot extract + olive oil) and group 4 (treated with GNLD Carotenoid complex + olive oil). The concentration of carrot extracted Carotenoid and that of the GNLD Carotenoid complex were 559mg/kg.The animals were sacrificed after 21 days of treatment and whole blood collected for analysis of immune parameters. The parameters included; percentage lymphocytes, percentage eosinophils, percentage monocytes and platelet count. There were significant increases (P<0.05) in groups 3 and 4 which received carrot extract and Carotenoid complex supplement when compared to group 1 and 2 which received distilled water and olive oil. This supports the claim that Carotenoids have immunomodulatory effects. However, it is clear that there were significant increases (P<0.05) in percentage lymphocytes (40.15± 1.33), monocytes (2.50± 1.31), neutrophils (60.08± 2.06) and platelet count (7.91± 0.53) in group 4 which received carotenoid complex when compared to that of group 3 which received carrot extract; lymphocytes (33.01 ± 3.20), monocytes (1.52 ± 0.52), neutrophils (60.12 ± 1.50) and platelet count (7.81 ± 0.52).These significant increases(P<0.05) show that both carotenoids have immunomodulatory effects; and that the GNLD Carotenoid complex which consists of alpha-carotene, beta-carotene, lutein, Zeaxanthin, beta-cryptoxanthin, lycopene and alpha-tocopherol is more potent in its immunomodulatory effect compared to the carrot extracted carotenoid which contained mostly alpha-carotene and beta-carotene alone.

Keywords
Carotenoids, Carrot, immunomodulatory effect, GNLD, white blood cells, platelet count

 
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