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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 21, No. 1-2, 2006, pp. 31-35
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Bioline Code: np06007
Full paper language: English
Document type: Research Article
Document available free of charge
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Nigerian Journal of Physiological Sciences, Vol. 21, No. 1-2, 2006, pp. 31-35
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SAFETY AND HYPOGLYCAEMIC PROPERTIES OF AQUEOUS LEAF EXTRACT OF OCIMUM GRATISSIMUM  IN STREPTOZOTOCIN INDUCED DIABETIC RATS.
U. G. EGESIE, A. B. ADELAIYE J. O. IBU, and O. J. EGESIE
Abstract
The claim by Nigerian traditional herbal medicine practitioners that Ocimum gratissimum leaves have antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin and graded doses of the aqueous leaf extract were administered orally to the experimentally diabetic rats for 28 days. Administration of the aqueous leaf extract caused a statistically significant reduction in plasma glucose level in streptozotocin induced diabetic rats. The extract appeared nontoxic as evidenced by normal serum levels of AST, ALT, ALP, TPT, ALB and bilirubin. These data appear to agree with claimed hypoglycaemic effects of Ocimum gratissimum.
Keywords
Ocimum gratissimum; Diabetes mellitus; Hypoglycaemia, Liver enzymes.
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© Copyright 2006 - Physiological Society of Nigeria
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