Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
Vol. 22, No. 1-2, 2007, pp. 43-47
Bioline Code: np07007
Full paper language: English
Document type: Research Article
Document available free of charge
Nigerian Journal of Physiological Sciences, Vol. 22, No. 1-2, 2007, pp. 43-47
© Copyright 2007 - Physiological Society of Nigeria
EFFECT OF MEFLOQUINE ON THE MECHANICAL ACTIVITY OF THE MOUSE ISOLATED RECTAL SMOOTH MUSCLE|
UNEKWE, P. C.; OGAMBA, J. O.; CHILAKA, K. C. & OKONKWO, J. C.
The effects of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle was studied. Mefloquine (4.1x10-5 - 5.2x10-3M) when applied alone and separately exerted variable effects on the rectum. In some preparations, it caused slight phasic contractions while in others no response was elicited. When the external (Ca2+) was increased from 1.8mM to 300mM mefloquine produced phasic contractile activity which was abolished on return to normal 1.8mM suggesting that the contractile activity was due to extracellular Ca2+ influx. Meflaquine (4.1x10-6M – 4.1x10-4M) caused contraction – dependent inhibition of KCL, Carbachol and CaCl2 (in depolarizing Tyrode Solution). Mefloquine (2.1x10-4M) blocked KCL, but not carbachol contractions which were largely reversed by increasing (Ca2+). The results show that mefloquine possesses anticholinergic and appreciable calcium channel blocking activity.
Mefloquine, mouse rectal muscle, contraction.