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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 22, No. 1-2, 2007, pp. 65-68
Bioline Code: np07011
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 22, No. 1-2, 2007, pp. 65-68

 en SERUM PROTEIN AND ENZYME LEVELS IN RATS FOLLOWING ADMINISTRATION OF ANTIOXIDANT VITAMINS DURING CAFFEINATED AND NON-CAFFEINATED PARACETAMOL INDUCED HEPATOTOXICITY
EKAM, V. S. & EBONG, P. E.

Abstract

The effects of caffeinated and non-caffeinated paracetamol administration, with or without vitamins A and E supplementation on the protein and enzyme levels in Wistar albino rats were investigated using cafeinated paracetamol and paracetamol as caffeinated and non-caffeinated paracetamol respectively, and water soluble acetic acid derivatives of vitamins A and E. Serum AST, ALT and ALP levels (u/l) significantly increased (P<0.05) following paracetamol administration. Caffeination as well as administration of vitamins A and E caused significant decreases (P<0.05) in AST and ALP levels in all test groups when co-administered with paracetamol and in ALT level except in the cafeinated paracetamol + Vitamin E group in which ALT and ALP level except in the cafeinated paracetamol + vitamin E group in which ALT and ALP levels significantly increased (P<0.05). Total serum protein level (g/100ml) significantly increased following caffeination as well as during co-administration of cafeinated paracetamol and Vitamin E; and significantly decreased during co-administration of paracetamol and vitamin A. Paracetamol administration without caffeination or supplementation with vitamin A and E can therefore cause increases in serum liver enzymes that is suggestive of liver necrosis which can be ameliorated to varying degrees by caffeine, vitamin A and E.

Keywords
Paracetamol, liver enzymes, cafeinated paracetamol, vitamins A and E

 
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