search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 22, No. 1-2, 2007, pp. 75-81
Bioline Code: np07013
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 22, No. 1-2, 2007, pp. 75-81

 en EFFECT OF CAFFEINE -COCONUT PRODUCTS INTERACTIONS ON INDUCTION OF MICROSOMAL DRUG-METABOLIZING ENZYMES IN WISTAR ALBINO RATS
ABARA, A. E.; OBOCHI, G. O.; MALU, S. P.; OBI-ABANG, M.; EKAM, S. & UBOH, F. U.

Abstract

Effect of caffeine-coconut products interactions on induction of drug-metabolizing enzyme in wistar albino rats was studied. Twenty rats were randomly divided into four groups: The control group (1) received via oral route a placebo (4.0ml of distilled water). Groups 2 to 4 were treated for a 14-day period with 50mg/kg body weight of caffeine, 50mg/kg body weight of caffeine and 50mg/kg body weight of coconut water, and 50mg/kg body weight of caffeine and 50mg/kg body weight of coconut milk in 4.0ml of the vehicle via gastric intubation respectively. One day after the final exposure, the animals were anaestheticized by inhalation of an overdose of chloroform. The blood of each rat was collected by cardiac puncture while the liver of each rat was harvested and processed to examine several biochemical parameters, ie, total protein and RNA levels, protein/RNA ratios, and activities of alanine and aspartate amino transferase (ALT and AST, respectively). The results showed that while ingestion of coconut milk and coconut water increased the values of protein and protein/RNA ratios, it decreased alanine and aspartate amino transferase (ALT and AST) activities. These effects, in turn, enhanced the induction of the metabolizing enzymes and a resultant faster clearance and elimination of the caffeine from the body, there by reducing the toxic effect on the liver.

Keywords
Coconut water, coconut milk, caffeine, protein, RNA, aminotransferases, liver and enzymes.

 
© Copyright 2007 - Physiological Society of Nigeria

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 27-Jul-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil