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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 22, No. 1-2, 2007, pp. 83-87
Bioline Code: np07014
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 22, No. 1-2, 2007, pp. 83-87

 en HAEMATOPOIETIC PROPERTIES OF ETHANOLIC LEAF EXTRACT OF AGERATUM CONYZOIDES check for this species in other resources (GOAT WEED) IN ALBINO RATS.
ITA, S. O.; ETIM, O. E.; BEN, E. E. & EKPO, O. F.

Abstract

The potential haematological effects associated with the administration of ethanolic leaf extract of AGERATUM CONYZOIDES check for this species in other resources was investigated in rats. 27 rats were randomly divided into four groups. The first group had 6 rats and served as control, the remaining 3 experimental groups and had 7 rats each. These later groups were gavaged with the extract of Ageratum conyzoides in concentrations of 200mg/kg, 400mg/kg and 500mg/kg respectively for 30days at a dose of 0.1ml/body weight. The control group was gavaged with 0.9% sodium chloride at a dose of 0.1m1/body weight as placebo. The extract at the doses administered was found to increase in a dose-related fashion PCV and Hb (p<0.01 for 200mg/kg and p<0.001 for 400mg/kg and 500mg/kg), RBC (P<0.05 for 400mg/Kg and 500mg/kg) and marginal increases that were not significant (P>0.05 for 200mg/kg); MCH and MCV (P<0.05 and P<0.01 for 400mg/kg and 500mg/kg respectively) 200mg/kg was not significant. MCHC recorded no significant change. WBC recorded marginal increases that were not significant (P>0.05), similarly, the differential white blood cell recorded marginal increases that were not significant, except lymphocytes that recorded significant increase in group 4 (P<0.05). Marginal Decreases in body weight were also observed, these decreases were however not significant. The result of this study thus indicate haematopoietic potentials of the extract and could possibly remedy anaemia.

Keywords
Ageratum conyzoides, rats, haemoglobin, white blood cell, haemopoietic potential, anaemia.

 
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