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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 25, No. 1, 2010, pp. 2-4
Bioline Code: np10002
Full paper language: English
Document type: Review Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 25, No. 1, 2010, pp. 2-4

 en You Can Get There From Here: Acetone, Anionic Ketones and Even-Carbon Fatty Acids can Provide Substrates for Gluconeogenesis
Glew, Robert H

Abstract

Although the literature contains studies published more than 30 years ago showing that acetone is not metabolically inert, it is common to find biochemistry textbooks and current research publications asserting that acetone is a ‘dead-end’ metabolite. In fact, acetone derived from the non-enzymatic breakdown of acetoacetate in ketotic individuals or from the oxidation of ingested isopropanol can be metabolized to D-lactate and pyruvate, and ultimately glucose. This report describes the reactions and pathways that account for the metabolism of acetone in humans.

Keywords
gluconeogenesis, ketones, acetone, acetoacetate, glucose, fatty acid metabolism, even-carbon fatty acids

 
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