Leave (Anacardiaceae), a plant natively grown in wastelands in Africa is used as a
folk remedy for diabetes mellitus. Previous studies, reported the hypoglycemic effect of the aqueous leaf extract of A.
occidentale in diabetic rats and its prophylactic activity against the diabetogenic action of streptozotocin This study
evaluated the hypoglycemic effect of a methanolic extract of streptozotocin leaves and its fractions in Alloxan-induced
diabetic rats in comparison to Tolbutamide, a reference drug. For moderately diabetic rat, A. occidentale
caused a 79.2 %
change over 4 hours and Tolbutamide caused a 63.1 % change over this same time period. When the rat were considered to
be severely diabetic, the A. occidentale
decreased the blood glucose levels by 20.8% change over four hours and the mean
percent change over 4 hours for Tolbutamide was 47.63 %. These values were not considered significant (p>0.05). So the
same conclusion can be made about the efficacy of A. occidentale
, when compared to the reference drug, Tolbutamide.
These results that show that A. occidentale
has a similar ability compared with Tolbutamide to lower
blood glucose levels.