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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 25, No. 2, 2010, pp. 181-186
Bioline Code: np10030
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 25, No. 2, 2010, pp. 181-186

 en Effect of Aqueous Fruit Extract of Xylopia Aethiopica check for this species in other resources on Intestinal Fluid and Glucose Transfer in Rats
Okwari, O.O.; Nneli, R. O & Osim, E.E


Intestinal fluid and glucose absorption was studied in jejunal and ileal segments in Xylopia aethiopica check for this species in other resources fed rats using inverted sac technique. Thirty male Wistar rats were assigned into three groups of 10 rats each; control, 100mg/kg and 200mg/kg Xylopia aethiopica treated groups. The control group received normal rat chow and water while the low dose and high dose groups received oral administration of Xylopia aethiopica extract at doses of 100mg/kg and 200mg/kg body weight respectively in addition to daily rat chow and water intake for 28 days. The results showed significant reduction and increase in fluid transfer in the jejunum and ileum respectively (P<0.01) compared with control. 100mg/kg increased gut fluid uptake in the ileum while 200mg/kg treatment reduced uptake in jejunum compared with control. Both doses had significantly increased jejunal and ileal glucose transfer. Gut glucose uptake was increased in jejunum and ileum of Xylopia aethiopica treated groups. Both doses increased the crypt depth but significantly decreased the villus height in the ileum (P<0.05). In conclusion, increased ileal gut fluid uptake may be beneficial in diarrheal state while an enhanced glucose uptake implies that glucose substrate may be made available to cells for synthesize of ATP for cellular activities.

Xylopia aethiopica, Glucose, Absorption, Jejunum, Ileum, Rat

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