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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 32, No. 2, 2017, pp. 201-205
Bioline Code: np17032
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 32, No. 2, 2017, pp. 201-205

 en Modulatory Role of Rutin Supplement on Open Space Forced Swim Test Murine Model of Depression
Yusha’u, Y.; Muhammad, U. A.; Nze, M.; Egwuma, J.M.; Igomu, O.J. & Abdulkadir, M.

Abstract

Summary: Flavonoids have been demonstrated to possess an anti-depressant effect and less adverse effects than tricyclic anti-depressants. For this reason, flavonoids in natural products have attracted growing attention. Rutin is a glycoside flavonoid which belongs to an important class of flavonoids, abundantly found in plants, such as buckwheat seeds, asparagus, red pepper, apples, citrus fruits and leaves of many herbs such as rosemary, dandelion or sage, and black and green tea. It is a vital nutritional component of food stuff. This study aimed at investigating the antidepressant potential of the rutin supplement on Swiss albino mice. For assessment of antidepressant activity, Open Space Forced Swim Test (OSFST), Tail Suspension Test (TST), Open-Field Test (OFT) and Novel Object Recognition Test (NORT) were used. Twenty-five Swiss albino mice were used for the study and divided into five groups. Group I received 10 mg/kg distilled water, group II received fluoxetine 20 mg/kg while group III, IV and V received rutin (30 mg/kg, 60 mg/kg and 120 mg/kg respectively) for sixteen days. The administration of the rutin supplement for sixteen days produced a reduction of immobility time in the TST (at 30 mg/kg, 60 mg/kg and 120 mg/kg), p<0.05. Likewise, a statistically significant difference was observed in line crossing in OFT, p<0.05. However, no significant effect was observed in percentage novel object preference in NORT. This study revealed that oral administration of rutin has an antidepressant potential in a dose dependent manner in OSFST mouse model of depression.

Keywords
Rutin; Flavonoids; Antidepressants; Immobility; Fluoxetine

 
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