The African Journal of Neurological Sciences Vol 17 No.1,
1998
The physiopathology of cerebral malaria
TOUZE J.E., VAN de WALLE J.P., FOURCADE I., MAFART B.,
LAROCHE R.
Code Number: NS98002
SUMMARY
A review of old and new pathogenetic hypothesis is presented
with criticism in the case of the sludge theory and the
permeability hypothesis. The hypothesis of cytoadherence is
supported and complimented by the concept of cytokine secretion and
host-disease interaction. Although some of the view expressed (use
of dexameyhazone and quinine) are not universally accepted, the
article offers a modern view on this complex matter.
RESUME
Les anciennes et nouvelles hypotheses concernant la
pathogenese du paludisme sont presentees et la theorie de
l'agglutination et de la permeabilite discutee. L'hypothese de la
cytoadherence repose sur le concept de la secretion de cytokine et
de l'interaction hote-maladie. Bien que certains des points de vue
exprimes, l'utilisation de la dexamethazone et de la quinine en
particulier, ne soient pas acceptes par tous, l'article apporte un
regard nouveau sur ce sujet comlexe.
KEY WORDS: Cerebral Malaria-physiopathology
Copyright 1998 Pan African Association of Neurological
Sciences
