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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. 1, 2000, pp. 75-80
Bioline Code: oc00011
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. 1, 2000, pp. 75-80

 en Palaearctic Origin of Leishmania
Sara F Kerr

Abstract

The hypothesis of a Palaearctic origin of Leishmania in the early Cenozoic, dispersal to the Nearctic in the late Eocene and to the Neotropical in the Pliocene is presented. It is further hypothesized that murid rodents and their immediate ancestors have been important mammalian reservoirs since the origination of Leishmania. Biochemical, molecular, biogeographical, entomological, mammalalogical and ecological support for these hypotheses are reviewed.

Keywords
Leishmania mexicana - Leishmania major - Endotrypanum - Sauroleishmania - Sigmodontinae - Muridae - Lutzomyia - Phlebotomus - Sergentomyia - coevolution - biogeography

 
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