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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. 3, 2000
Bioline Code: oc00059
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. 3, 2000

 en Aotus infulatus Monkey is Susceptible to Plasmodium falciparum check for this species in other resources Infection and May Constitute an Alternative Experimental Model for Malaria
Leonardo JM Carvalho; Salma G Oliveira; Francisco A Alves; Maria CO Brgido; Jos APC Muniz & Claudio T Daniel-Ribeiro

Abstract

Aotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum check for this species in other resources or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria.

Keywords
Aotus infulatus, Plasmodium falciparum, malaria, primate model

 
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