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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. 4, 2000, pp. 495-501
Bioline Code: oc00078
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. 4, 2000, pp. 495-501

 en A GBP 130 Derived Peptide from Plasmodium falciparum Binds to Human Erythrocytes and Inhibits Merozoite Invasion in Vitro
Jorge E Suarez; Mauricio Urquiza; Hernando Curtidor; Luis E Rodriguez; Marisol Ocampo; Elizabeth Torres; Fanny Guzman & Manuel Elkin Patarroyo


The malarial GBP 130 protein binds weakly to intact human erythrocytes; the binding sites seem to be located in the repeat region and this region's antibodies block the merozoite invasion. A peptide from this region (residues from 701 to 720) which binds to human erythrocytes was identified. This peptide named 2220 did not bind to sialic acid; the binding site on human erythrocyte was affected by treatment with trypsin but not by chymotrypsin. The peptide was able to inhibit Plasmodium falciparum merozoite invasion of erythrocytes. The residues F701, K703, L705, T706, E713 (FYKILTNTDPNDEVERDNAD) were found to be critical for peptide binding to erythrocytes.

Plasmodium falciparum, GBP 130, binding assay

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