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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. 5, 2000, pp. 729-732
Bioline Code: oc00115
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. 5, 2000, pp. 729-732

 en Multiple Isolates from Aids Patients: Aspects of an Analysis by a Genotypic Marker and Antimicrobial Susceptibilities Variations
Maria Helena Fres Saad; Maria Alice Telles; Ftima Porfirio; Lucilaine Ferrazoli; Leila de Souza Fonseca; Warren Johnson Jr & Lee W Riley

Abstract

Twenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harboring multisolates with different fingerprint profile, were therefore considered as having a polyclonal infection, since their isolates were taken from sterile site. This result confirms that polyclonal infection caused by M. avium occurs with a nonnegligenciable frequency. Analyzing the multisolates susceptibility profile of each patient it was observed that most of them were infected with strains having appreciably different antimicrobial susceptibility patterns, no matter what the genotypic pattern of the strains was. These results have strong implication for the treatment of the patients.

Keywords
Mycobacterium avium, polyclonal infection, susceptibility test

 
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