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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. s1, 2000, pp. 171-173
Bioline Code: oc00176
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. s1, 2000, pp. 171-173

 en Aspects of Gastrointestinal Immunology and Nutrition in Human Immunodeficiency Virus-1 Infection in Brazil
Luiz RR Castello-Branco & Maria Beatriz Ortigo-de-Sampaio


Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.

gastrointestinal immunology, human immunodeficiency virus-1 infection, nutrition, mucosal immunology

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