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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 95, No. s1, 2000, pp. 175-178
Bioline Code: oc00177
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 95, No. s1, 2000, pp. 175-178

 en Studies on the Virulence and Attenuation of Trypanosoma cruzi Using Immunodeficient Animals
Miguel Ángel Basombro; María Asunción Segura; Laura Gómez & Marcelo Padilla

Abstract

Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines with low infectivity for mammals. One such subline (TCC clone) has been extensively used in our laboratory as experimental vaccine and tested in comparative experiments with its virulent ancestor (TUL). The experiments here reviewed aimed at the use of immunodeficient mice for testing the infectivity of TCC parasites. It has not been possible to obtain virulent, revertant sublines by prolonged passaged in such mice.

Keywords
Trypanosoma cruzi, immunosuppression, athymic mice, attenuation

 
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