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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 95, No. s1, 2000, pp. 201-206
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Bioline Code: oc00182
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 95, No. s1, 2000, pp. 201-206
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Mosquitocidal Bacterial Toxins: Diversity, Mode of Action and Resistance Phenomena
Jean-François Charles & Christina Nielsen-LeRoux
Abstract
Bacteria active against dipteran larvae (mosquitoes and black flies) include a wide variety of Bacillus thuringiensis and B. sphaericus strains, as well as isolates of Brevibacillus laterosporus and Clostridium bifermentans. All display different spectra and levels of activity correlated with the nature of the toxins, mainly produced during the sporulation process. This paper describes the structure and mode of action of the main mosquitocidal toxins, in relationship with their potential use in mosquito and/or black fly larvae control. Investigations with laboratory and field colonies of mosquitoes that have become highly resistant to the B. sphaericus Bin toxin have shown that several mechanisms of resistance are involved, some affecting the toxin/receptor binding step, others unknown.
Keywords
Bacillus thuringiensis, Bacillus sphaericus, Brevibacillus laterosporus, Clostridium bifermentans, toxin binding, receptor, resistance
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© Copyright 2000 Fundacao Oswaldo Cruz Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
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