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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 3, 2001, pp. 349-351
Bioline Code: oc01051
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 3, 2001, pp. 349-351

 en Effect of Lutzomyia whitmani (Diptera: Psychodidae) Salivary Gland Lysates on Leishmania (Viannia) braziliensis Infection in BALB/c Mice
Celso Luíz Cardoso; Luiz Roberto Bigão Giacomelli; César Helbel; Janete Jordão Sant'Ana; Fátima Moreira Martins & Angela Maria Werneck Barreto

Abstract

Previous reports showed that Lutzomyia longipalpis saliva exacerbate Leishmania braziliensis infection in mice. The sand fly Lu. whitmani is one of the vectors of L. (Viannia) braziliensis (LVb), a causative agent of cutaneous leishmaniasis in the State of Cear, Brazil. To determine whether saliva of Lu. whitmani could increase the infectivity of LVb in mice, we inoculated groups of BALB/c mice with LVb promastigotes in the presence or absence of the salivary glands lysate from Lu. whitmani. We found that coinjection with Lu. whitmani saliva increased size but not longevity of cutaneous LVb lesions in BALB/c mice, since the formed lesions gradually resolved. The mechanism(s) by which Lu. whitmani saliva might exacerbate LVb infection in BALB/c mice is speculated.

Keywords
Leishmania braziliensis, saliva, Lutzomyia whitmani, BALB/c mice

 
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