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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 4, 2001, pp. 515-518
Bioline Code: oc01078
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 4, 2001, pp. 515-518

 en Detection of the Acute Phase of Abdominal Angiostrongyliasis with a Parasite-specific IgG Enzyme Linked Immunosorbent Assay
Stefan Michael Geiger; Antônio Carlo Laitano; Charlotte Sievers-Tostes; Aventino Alfredo Agostini; Hartwig Schulz-Key & Carlos Graeff-Teixeira

Abstract

Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months) after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis.

Keywords
abdominal angiostrongyliasis-serology-eosinophilic gastroenteritis-immunodiagnosis

 
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