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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 4, 2001, pp. 545-548
Bioline Code: oc01083
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 4, 2001, pp. 545-548

 en Morphometry of Submucous and Myenteric Esophagic Plexus of Dogs Experimentally Reinfected with Trypanosoma cruzi
Evandro MM Machado; Deolino J Camilo Júnior; Simone W Pinheiro; Edison Reis Lopes; Alexandre J Fernandes; João Carlos Pinto Dias & Sheila J Adad

Abstract

We carried out a morphometric study of the esophagus of cross-bred dogs experimentally infected or consecutively reinfected with Trypanosoma cruzi 147 and SC-1 strains, in order to verify denervation and/or neuronal hypertrophy in the intramural plexus. The animals were sacrificed in the chronic stage, 38 months after the initial infection. Neither nests of amastigotes, nor myositis or ganglionitis, were observed in all third inferior portions of esophageal rings analyzed. No nerve cell was identified in the submucous of this organ. There was no significant difference (p>0.05) between the number, maximum diameter, perimeter, or area and volume of the nerve cells of the myenteric plexus of infected and/or reinfected dogs and of the non-infected ones. In view of these results we may conclude that the 147 and SC-1 strains have little neurotropism and do not determine denervation and/or hypertrophy in the intramural esophageal plexuses in the animals studied, independent of the reinfections.

Keywords
Chagas disease, Trypanosoma cruzi, dog, reinfection, esophagus, myenteric plexus

 
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