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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 5, 2001, pp. 673-678
Bioline Code: oc01105
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 5, 2001, pp. 673-678

 en In Vivo Lymphocyte Activation and Apoptosis by Lectins of the Diocleinae Subtribe
Theolis Barbosa; Sérgio Arruda; Benildo Cavada; Thalles Barbosa Grangeiro; Luiz Antônio Rodrigues de Freitas & Manoel Barral-Netto


This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.

adjuvants, apoptosis, Diocleinae, lectin

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