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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 6, 2001, pp. 831-833
Bioline Code: oc01134
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 6, 2001, pp. 831-833

 en Polygodial, the Fungitoxic Component from the Brazilian Medicinal Plant Polygonum punctatum
Tânia Maria de Almeida Alves; Fabiane Lacerda Ribeiro; Helmut Kloos & Carlos Leomar Zani

Abstract

Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay with the fungus Cladosporium sphaerospermum. The bioassay-guided chemical fractionation of this extract afforded the sesquiterpene dialdehyde polygodial as the active constituent. The presence of this compound with antibiotic, anti-inflammatory and anti-hyperalgesic properties in "erva-de-bicho" may account for the effects attributed by folk medicine to this plant species.

Keywords
medicinal plants, Cladosporium sphaerospermum, antifungal, polygodial, sesquiterpene, Brazil

 
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