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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. s1, 2001, pp. 89-101
Bioline Code: oc01157
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. s1, 2001, pp. 89-101

 en T Cell Clones from Schistosoma haematobium check for this species in other resources Infected and Exposed Individuals Lacking Distinct Cytokine Profiles for Th1/Th2 Polarisation
T Mduluza; PD Ndhlovu; N Midzi; C Mary; CP Paris; CMR Turner; SK Chandiwana; MEJ Woolhouse; AJ Dessein & P Hagan

Abstract

T cell clones were derived from peripheral blood mononuclear cells of Schistosoma haematobium check for this species in other resources infected and uninfected individuals living in an endemic area. The clones were stimulated with S. haematobium check for this species in other resources worm and egg antigens and purified protein derivative. Attempts were made to classify the T cell clones according to production of the cytokines IL-4, IL-5 and IFN-g. All the T cell clones derived were observed to produce cytokines used as markers for the classification of Th1/Th2 subsets. However, the 'signature' cytokines marking each subset were produced at different levels. The classification depended on the dominating cytokine type, which was having either Th0/1 or Th0/2 subsets. The results indicated that no distinct cytokine profiles for polarisation of Th1/Th2 subsets were detected in these S. haematobium infected humans. The balance in the profiles of cytokines marking each subset were related to infection and re-infection status after treatment with praziquantel. In the present study, as judged by the changes in infection status with time, the T cell responses appeared to be less stable and more dynamic, suggesting that small quantitative changes in the balance of the cytokines response could result in either susceptibility or resistant to S. haematobium infection.

Keywords
Schistosoma haematobium, cytokines, T cell clones, immunoregulation, T helper subsets

 
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